Carnitine as a weight loss supplement
Before discussing carnitine for weight loss, we must first examine the disease of weight gain. Obesity is a severe health problem due to the higher price of health issues around the globe. With fat loss, it’s becoming hard in just this modern world; weight reduction is gaining so much focus. Anti-obesity narcotics had no adverse reactions to obtrusive cosmetic procedures, so they are more often utilized than in other alternatives like vigorous exercise. The mitochondrial enzyme has so far adhered to mitigating cardiovascular events, end-stage bladder diseases, dialysis-related heart problems, diagnosis of persistent depression, and recovery of non-alcoholic liver failure. Carnitine is one of the solutions to this growing issue as it burns the excess fats from our bodies. Its use as a weight-loss supplement was initiated in this century.
In this article, we will discuss why we need carnitine? Does it work for weight loss? Does it work for the fat burn? Is it correct up to all the hype that is out there? Metabolism and function of carnitine and its metabolism related to weight loss in humans and the availability of different supplements we use for weight loss. At the same time, we will also look at various other functions related to carnitine.
History of Carnitine
In 1905, carnitine was first discovered in meat extract. In 1927, the correct structure for carnitine was proposed. Next, in 1948, a new vitamin, BT, was found essential for the growth of the yellow mealworm. The T derives from the Latin name of this species, Tenebrio Molitor. Afterward, this Vitamin identifies as carnitine. After that discovery of this enzyme acetyltransferase (CRAT) takes place. And finally, in 1958, I.B. Fritz discovered that it stimulates long-chain fatty acid oxidation in mitochondria.
Meaning of Carnitine
This word comes from the Latin carnus (means flesh) and relates to the word carnivores. And it is first derived from meat. A four-ounce portion of steak has almost 100mgs of carnitine. But the supplemental dose that most people take is about 2 to 3 grams and also depends upon the diet a person consumes. At the same time, our body can also be made this by itself. It is a quaternary ammonium compound, also known as L-b-hydroxy-c-N-trimethyl aminobutyric acid.
The synthesis of this supplement takes place in a variety of organs. But the liver and kidneys seem to have the highest activity of carnitine synthesis. It acts as a transporter of long-chain fatty acid into the mitochondria. That can derive from our diet and can synthesize in the body. It synthesizes two essential amino acids in the body, lysine and methionine. But to produce it in a maximum amount, we need a large amount of vitamin C.
Here let’s take a look at how carnitine has been synthesized. This pathway is highly preserved as four critical enzymes have been utilized during this process. To begin the process of protein degradation. That results in the production of lysine residues, for example, trimethyl lysine. We can get it via the following reactions:
Now, this L carnitine would act as a mediator of transporting long-chain fatty acyl chain into the mitochondria for beta-oxidation that results in their destruction if we have more carnitine in the body. That can shuttle more fatty acid into the mitochondria; then, they can burn more fat.
Different types of Carnitine
Acetyl L-carnitine: This is often called ALCAR. This is possibly the effective form for your brain. Studies also suggest that it benefits people with neurodegenerative diseases.
D-carnitine: This inactive form of carnitine causes a deficiency in your body by inhibiting the absorption of other more useful forms of this element.
L-carnitine L-tartrate: This is commonly added to sports supplements due to its rapid absorption rate. It aids in muscle soreness and recovery from exercise.
Propionyl-L-carnitine: This form is well suited for circulatory issues such as peripheral vascular disease and high blood pressure. It boosts the production of nitric oxide, improving blood flow.
Functions of Carnitine in the human body
Burns excess fats: One of the most widely used functions of carnitine is that it converts fats and glucose into energy by metabolizing them. It increases the oxidation of long-chain fatty acids that help manage human weight loss. It reduces the stored amount of fat present in your body. This results in the enhancement of exercise performance of individuals, directly linking to their weight loss.
L-carnitine not only reduces the fat stored deep inside the belly that is wrapped around the organs. Such as the liver and intestine, thus decreasing the chances of fatty liver disorders and other health problems. It is therefore understood that it could aid your body’s energy production by metabolizing the carbohydrates and long heavy chains of lipids, thus providing you with the best way to lose weight. Evidence shows that it burns calories by growing calorie expenses.
Helping in weight loss (Maintaining muscle integrity): Although L carnitine help in the burning of fat tissues inside the body to produce energy, what if that energy is still not used up? It will again restore the form of fat in our bodies. That is why 3 to 4 hours of exercise per week recommend with its intake. Supplementing with it can also play an essential role in restoring the damage caused by intensive training.
This is because L carnitine provides an alternative energy source through fat breakdown instead of muscle glycogen for energy production, preventing lactic acid production in muscles. Including it in our routine enhances our muscle mass, resulting in a decrease in physical and mental fatigue and a reduction in body weight. Supplementation of L-carnitine also positively influences the recovery process after exercise.
Improves insulin sensitivity and weight loss: Carnitine enhances insulin sensitivity in people with diabetes, and this is super important because insulin sensitivity is directly related to weight loss. A more insulin-sensitive body means our body doesn’t have to release Tons of insulin to process carbohydrates constantly. It will then start burning fats.
Antioxidant effect: Carnitine also inhibits the oxidative damage of tissues. And act as a potent antioxidant (free radical scavenger). Studies show that oxidative stress influences the pathophysiology of many inherited neurometabolic disorders and the brain’s actions. As the center of their attention because of large oxygen consumption in the brain to provide energy. As it can easily cross the blood-brain barrier, L carnitine supplementation significantly prevents neurometabolic disorders.
Carnitine as a memory booster: The supplements have been increasingly used to boost memory and brain functions. It is also seen to be very fruitful in age-related dementia. L-carnitine also helps to increase fertility in men. This also enhances the blood flow toward the muscles. Heart energy is also coming mainly from fats and L carnitine. It also acts to catalyze our immune system.
The dosage of l-carnitine depends on the carnitine availability in your body and the body’s weight.
In adult males
It has been used only by adult males in portions of 2 grams per oral a day.
It has sometimes been used in oral doses of 50-100 mg/kg daily for up to 14 months.
NOTE: Feel free to talk to your medical practitioner to search out what pill might be better for a particular illness.
Supplements containing the fat burner Carnitine
Different supplements available are:
L carnitine 500 mg, L carnitine 1000 mg.
Liquid L carnitine syrup and ALCAR 500 mg are also available that you can use to get it for the maintenance of your body weight; it is a lipotropic injection for weight loss: A significant weight loss in people has been seen who had taken this lipotropic injection.
Safe use of Carnitine-containing supplements
If you try to lose weight, the recommended approved medical dose is 2grams or less carnitine per day. You must follow up with the doctor’s guidelines if you take other supplements for weight loss or dieting.
Natural sources that are rich in Carnitine you can use for fat control:
Different dairy products, including meat, fish, chicken, and pork, contain plenty of this. But their effect on the human body depends upon the appropriate way of using them and post-workout after their intake. The figure illustrates the approx. Amount of carnitine available in them:
Pregnancy: You must reside in the cautious zone and prevent its use. Because there is no authentic evidence that supports the use of L carnitine during pregnancy.
During lactation: These particles had no unique lactation-related uses. Within the conventional ballpark of diet, removing levocarnitine into breast milk is relatively continuous. This supplement is safe when taken orally or intravenously while breastfeeding in the quantities prescribed by the medical practitioner. A small amount of it has now been given to babies in lactation and formula, providing no reported side effects. Mothers with carnitine dysfunction seem to naturally produce insufficient quantities of carnitine into their breast milk for their nursed children. Who might otherwise need levocarnitine replacement therapy? Preterm babies and children are very often defective in levocarnitine and entail intake.
When given orally: It is likely peaceful when chosen to take for twelve weeks or as prescribed by the physician. Still, it could cause many side effects such as:
Stomach problems like stomach acid production, Nausea, Vomiting, Diarrhea, and Hallucinations. It also could affect the feces, breath, and moisture from the air’s feces, breath, and humidity to provide a “fishy” stench.
Try not to take D-carnitine and DL-carnitine. These kinds of carnitine might inhibit the effects of L-carnitine and produce diseases that depict L-carnitine deficit. Know L-carnitine diet interacts with certain antimicrobial drugs. Anybody thinking about taking L-carnitine should consult their general practitioner to discuss any pills. They are taking inappropriate medication connections.
Is L-carnitine good for weight loss in humans?
We are now familiar that L carnitine takes part in fat metabolism and aids in weight loss due to the complex nature of the human body. There is still a need for more research to confirm its use for weight loss. Let’s compare different meta-analyses. For example, comparing weight loss in women in an eight-week survey. The women who exercise four times a week lose their weight and found that there is no difference in losing weight between those who did take l carnitine and those who didn’t. At the same time, in a research study on obese people. Researchers have found that people taking it managed to lose about 2.9 pounds of weight more than those who did not.
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